FGF1 polyclonal antibody
产品名称: FGF1 polyclonal antibody
英文名称: FGF1 polyclonal antibody
产品编号: PAB4476
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of FGF1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human FGF1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Caspase-9 pathway activation by inhibiting endogenous fibroblast growth factor signaling in human glioma cells.
Fukushima S, Kato S, Maeda M, Shigemori M.Int J Oncol. 2008 Feb;32(2):467-73.
- 2.
- Sequence evaluation of FGF and FGFR gene conserved non-coding elements in non-syndromic cleft lip and palate cases.
Riley BM, Murray JC.Am J Med Genet A. 2007 Dec 15;143A(24):3228-34.
- 3.
- Fibroblast growth factor 1 gene and hypertension: from the quantitative trait locus to positional analysis.
Tomaszewski M, Charchar FJ, Lynch MD, Padmanabhan S, Wang WY, Miller WH, Grzeszczak W, Maric C, Zukowska-Szczechowska E, Dominiczak AF.Circulation. 2007 Oct 23;116(17):1915-24. Epub 2007 Oct 1.
- Applications
- Western Blot (Tissue lysate)
- Western blot analysis of FGF1 polyclonal antibody (Cat # PAB4476) in mouse kidney tissue lysates (35 ug/lane). FGF1 (arrow) was detected using the purified FGF1 polyclonal antibody (Cat # PAB4476) (1 : 60 dilution).
- Western Blot (Transfected lysate)
- Western blot analysis of FGF1 (arrow) using rabbit FGF1 polyclonal antibody (Cat # PAB4476). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FGF1 gene (Lane 2) (Origene Technologies).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human colon carcinomareacted with FGF1 polyclonal antibody (Cat # PAB4476), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 2246
- Protein Accession#:
- NP_000791;P05230
- Gene Name:
- FGF1
- Gene Alias:
- AFGF,ECGF,ECGF-beta,ECGFA,ECGFB,FGF-alpha,FGFA,GLIO703,HBGF1
- Gene Description:
- fibroblast growth factor 1 (acidic)
- Omim ID:
- 131220
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq
- Other Designations:
- OTTHUMP00000066028,OTTHUMP00000066030,OTTHUMP00000066031,OTTHUMP00000174675,endothelial cell growth factor, alpha,endothelial cell growth factor, beta,heparin-binding growth factor 1
- Interactome
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Arthritis, Psoriatic
- Cardiovascular Diseases
- Celiac Disease
- Chorioamnionitis
- Cleft Lip
- Cleft Palate
- Diabetes Complications
- Endometriosis
- Fetal Membranes, Premature Rupture
- Genetic Predisposition to Disease
- Hepatitis C, Chronic
- Hyperparathyroidism, Secondary
- Hypertension
- Intracranial Aneurysm
- Metabolic Syndrome X
- Multiple Sclerosis
- Neoplasms